Osterich's dagboek | Eten, trainen en beminnen. |

[Osterich]

"hoort bij de sport"

[Osterich]

Na een depressieve dag beurt dit mij weer op:

Tussendoor 1 appel of ander vruit

[Revius]

hij boekt vooruitgang

[Shredmaster]

Birth Date:05/21/79

Nationality:Brazil, Holland, Portugal

Een rotkop en veel te skinny, botje beuken zeg maar.
Mij niet gezien.

[Osterich]

YouTube - NK 2010, Figure Class

[Osterich]

Meerdere klasses door elkaar @ NK 2010.

[Osterich]

[Ashley]

Eindelijk gebanned....werd tijd ook.

[Revius]

miauw

[GeneralIx]

Hij is er nog hoor.

[Ashley]

Hij is er nog hoor.

Doodziek.

[Revius]

Kan me ook niet voorstellen dat hij weg is zonder een gepast afscheid

[Osterich]

Eindelijk gebanned....werd tijd ook.

Arachis hypogaea malus!

[Osterich]

Voor mezelf en de discussie die ik heb met meederen.
(nee ik zit er niet aan maar wil de wel/niet onderdruk discussie wel serieus nemen )

Severe thermal injury is associated with hypermetabolism and hypercatabolism, leading to skeletal muscle breakdown, lean body mass loss, weight loss, and negative nitrogen balance. Muscle protein catabolism in patients with severe thermal injury is the result of stress-induced increased release of cytokines and counterregulatory hormones. Coupled with decreased serum anabolic hormone concentrations such as testosterone and growth hormone along with the presence of insulin resistance, anabolism in patients with severe thermal injury is inefficient or impossible during the acute postburn period. This causes difficulty in restoring lean body mass and regaining lost body weight, as well as poor healing of the burn wound and delayed patient recovery. Oxandrolone, a synthetic derivative of testosterone, has been used in adult patients with severe thermal injury to enhance lean body mass accretion, restore body weight, and accelerate wound healing. In clinical studies, oxandrolone 10 mg orally twice/day improved wound healing, restored lean body mass, and accelerated body weight gain. During the rehabilitation period, oxandrolone therapy with adequate nutrition and exercise improved lean body mass, increased muscle strength, and restored body weight. However, most data on oxandrolone use in adult patients with severe thermal injury are derived from single-center studies, many of which enrolled a relatively small number of subjects and some of which had a poor design. Multicenter, prospective, randomized studies are needed to better define the optimal oxandrolone dosage and to confirm the efficacy and safety of this drug in adult patients with severe thermal injury.

PMID: 19170590 [PubMed - indexed for MEDLINE]

Joh, het werkt.

Abstract
OBJECTIVE AND SUMMARY BACKGROUND DATA: Postburn long-term oxandrolone treatment improves hypermetabolism and body composition. The effects of oxandrolone on clinical outcome, body composition, endocrine system, and inflammation during the acute phase postburn in a large prospective randomized single-center trial have not been studied. METHODS: Burned children (n = 235) with >40% total body surface area burn were randomized (block randomization 4:1) to receive standard burn care (control, n = 190) or standard burn care plus oxandrolone for at least 7 days (oxandrolone 0.1 mg/kg body weight q.12 hours p.o, n = 45). Clinical parameters, body composition, serum hormones, and cytokine expression profiles were measured throughout acute hospitalization. Statistical analysis was performed by Student t test, or ANOVA followed by Bonferroni correction with significance accepted at P < 0.05. RESULTS: Demographics and clinical data were similar in both groups. Length of intensive care unit stay was significantly decreased in oxandrolone-treated patients (0.48 +/- 0.02 days/% burn) compared with controls (0.56 +/- 0.02 days/% burn), (P < 0.05). Control patients lost 8 +/- 1% of their lean body mass (LBM), whereas oxandrolone-treated patients had preserved LBM (+9 +/- 4%), P < 0.05. Oxandrolone significantly increased serum prealbumin, total protein, testosterone, and AST/ALT, whereas it significantly decreased alpha2-macroglobulin and complement C3, P < 0.05. Oxandrolone did not adversely affect the endocrine and inflammatory response as we found no significant differences in the hormone panels and cytokine expression profiles. CONCLUSIONS: In this large prospective, double-blinded, randomized single-center study, oxandrolone shortened length of acute hospital stay, maintained LBM, improved body composition and hepatic protein synthesis while having no adverse effects on the endocrine axis postburn, but was associated with an increase in AST and ALT.

[Ashley]

Arachis hypogaea malus!

Kan het niet vinden....